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[Bioengineering]
- Adam Arkin [Link]
The Arkin laboratory seeks to uncover the evolutionary design principles of cellular networks and populations and to exploit them for applications. To do so they are developing a framework to effectively combine comparative functional genomics, quantitative measurement of cellular dynamics, biophysical modeling of cellular networks, and cellular circuit design to ultimately facilitate applications in health, the environment, and bioenergy.
>> math;;; 왜 publication 정보가 없지.. 뭐 그닥? ;
- Patricia Babbitt [Link]
We are studying protein structure-function relationships viewed from the perspective of evolutionarily related proteins in superfamilies. The idea is that by understanding how nature has re-engineered a given protein scaffold for a variety of functions, we gain insight about the fundamental rules by which protein structure mediates function. These computational analyses have led to new models for enzyme evolution, thereby providing a conceptual framework for inference of functional capabilities from structural information. This work has been successfully applied to such problems as the prediction of function for unknown reading frames and to provide guidance for experimental protein engineering. The wet bench side of the lab focuses on testing these models using both rational design and combinatorial approaches to generate proteins with specific new functions.
>> 논문 두개 뽑았음.
- Michelle C. Chang [Link]
Our research laboratory utilizes the approaches of mechanistic biochemistry, molecular and cell biology, metabolic engineering, and synthetic biology to address problems in energy and human health. We design and create new biosynthetic pathways in microbial hosts for in vivo production of biofuels from abundant crop feedstocks and pharmaceuticals from natural products or natural product scaffolds. A unifying theme of all of our projects is a focus on gaining a detailed molecular understanding of how living cells control enzymatic processes within the context of the entire metabolic network. Specific projects under current investigation include (i) the in vivo production of biofuels from plant biomass, and (ii) the development of new biosynthetic methods for selective, catalytic C-F bond formation under mild conditions.
- Jhih-Wei Chu [Link]
Our research program aims to understand how the atomistic scale information of biomolecules (chemistry) governs processes occurring at larger scales in the cell (biology) and applies this knowledge in therapeutic discovery, protein engineering and stabilization, biomaterial science, and the design of molecular devices (engineering). For this purpose, computational methodologies that can be used to propagate information across multiple temporal and spatial domains are being developed and applied to study various biomolecular systems. Current research projects include the allosteric modulation of membrane receptors, mechanical responses of biomolecules, effects of shear on protein conformation and protein-protein interactions, protein stability at oil/water interfaces, and the self-assembly of biomaterials.
* 특기사항: 랩에 한국 학생이 있음!
>> 뭔소린지 잘 모르겠음
- Thomas E. Ferrin [Link]
My research involves the development of computational tools that will increase our understanding of living systems through our study of sequence-structure-function relationships. Of central importance is the collection, storage, analysis, prediction and visualization of biological data at widely different scales from atoms to supramolecular assemblies. The results of these endeavors include scientific advances through publication, innovative software, primary and derived data, new standards, and educational resources.
* 특기사항: 멤버 정보가 없다;; 사람 뽑긴 하는건가....
- Jay Keasling [Link]
The Keasling Lab combines the development and application of synthetic biology tools with a comprehensive understanding of microbial physiology to tackle challenging high-impact problems. We aim to provide lasting solutions in such areas as environmental biotechnology, renewable energy, and biosynthetic production of theurapeutic molecules.
- Han Lim [Link]
The Lim Lab studies the design, properties and evolution of genetic circuits. We are particularly interested in genetic circuits that regulate the amount of phenotypic diversity ("noise") in populations of genetically identical cells. Much of work focuses on systems involved in bacterial survival and pathogenesis with the aim of providing new strategies to combat infectious disease. Our research examines mechanisms at the molecular, cellular, population and ecological levels using a combination of theoretical and experimental approaches. Current areas of interest include: the role of genetic noise in regulating diversity biological systems, epigenetic control of gene expression; information processing at cis-regulatory sequences; and RNA signalling cascades.
>> 최근 publication이 없다?? ;;
- Christopher Voigt [Link]
We are developing a basis by which cells can be programmed like robots to perform complex, coordinated tasks for pharmaceutical and industrial applications. We are engineering new sensors that give bacteria the senses of touch, sight, and smell. Genetic circuits - analogous to their electronic counterparts - are built to integrate the signals from the various sensors. Finally, the output of the gene circuits is used to control cellular processes. We are also developing theoretical tools from statistical mechanics and non-linear dynamics to understand how to combine genetic devices and predict their collective behavior.
>> 논문 몇개 골랐음. alumni중에 한국인이 있다.
[Molecular & Cell Biology]
- Tom Alber [Link]
'the molecular basis for protein recognition and signalling'
Our interests focus on defining the molecular logic of regulatory circuits in physiology and disease. An immediate challenge is to understand how protein interactions control biochemical reactions. To investigate the fundamental problems of molecular recognition and signaling, the primary tools we use are X-ray crystallography, molecular biology, genomics and physical biochemistry.
- James Berger [Link]
Our research interests lie in understanding the molecular basis of protein assembly and function. In particular, we aim to develop mechanistic models that explain how proteins physically exploit shape and chemistry to form large complexes and transduce energy into work. The primary focus of my group's investigations is on proteins that replicate, manipulate, and organize nucleic acids in the cell, and on metabolic enzymes required for maintaining nucleic acids in the pathogenic bacterium, M. tuberculosis. A combination of structural analyses, such as X-ray crystallography, small-angle X-ray scattering and EM, coupled with biphysical and biochemical experimentation, forms the core of our methodological approach.
* 특기사항: 한국인 포닥이 있음...
- Jennifer A. Doudna [Link]
RNA molecules are uniquely capable of encoding and controlling the expression of genetic information, often as a consequence of their three-dimensional structures. We are interested in understanding RNA-mediated initiation of protein synthesis, and RNA-protein complexes involved in targeting proteins for export out of cells. We are also investigating the early steps in gene regulation by RNA interference.
* 특기사항: 한국인 포닥이 있음... 원생 넷에 포닥 열 -_
- Michael B. Eisen [Link]
Current Projects in the Lab
* Comprehensive characterization of the regulatory network in the early Drosophila embryo
* Identification of regulatory sequences in Drosophila
* Characterizing the evolution of gene regulation in fungi
* Developing a theory of the molecular evolution of regulatory sequences
* Using genomic tools to study ecology and amphibian decline
* Enhancer identification by comparative genomics requires abundant non-conserved DNA
* Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
- Nicole King [Link]
We study choanoflagellates and the evolution of multicellular animals from their unicellular ancestors.
The origin of animals represents one of the pivotal transitions in life's history, and one of its greatest unsolved mysteries. While the fossil record remains silent regarding the rise of multicellularity, the genetic and developmental foundations of animal origins may be deduced from shared elements among extant animals and their protozoan relatives, the choanoflagellates. To better understand the origin and evolution of animals, our goals are to [1] determine the minimal genomic complexity of the common ancestor of animals, [2] elucidate the ancestral functions of genes required for multicellular development, [3] characterize choanoflagellate cell and developmental biology, and [4] test the hypothesis that the emergence of multicellular animals stemmed, in part, from the evolution of new modes of gene regulation.
>> 논문 뽑음!
- Judith Klinman [Link]
The overall focus of our research is the determination of fundamental principles of catalytic and regulatory mechanism in enzyme-catalyzed reactions. Our experimental approach is broadly based and combines kinetic, spectroscopic, stereochemical, and molecular biological techniques.
- John Kuriyan [Link]
The Kuriyan laboratory is interested in the structure and mechanism of the enzymes and molecular switches that carry out cellular signal transduction and DNA replication. We use x-ray crystallography to determine the three-dimensional structures of proteins involved in signaling and replication, as well as biochemical, biophysical, and computational analyses to figure out how they work. Two major focuses in the laboratory are understanding the allosteric mechanisms that enable proteins to be exquisitely sensitive to input signals and processive DNA repliaction.
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